Product Description

Catenin-γ (731) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1042-50, BS1042-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The catenins, α, β and γ, are proteins which bind to the highly conserved, intracellμlar cytoplasmic tail of E-cadherin. Together, the catenin/cadherincomplexes play an important role mediating cellμlar adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecμle. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regμlate complex signaling.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Junction plakoglobin, Catenin gamma, Desmoplakin-3, CTNNG, DP3, JUP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 700-750 of Human Catenin-γ.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Catenin-γ (731) polyclonal antibody detects endogenous levels of Catenin-γ protein.

Molecular Weight: ~ 82 kDa

Pathway: Contribution of ECM and Cytoskeletal Factors to EMT, Adherens Junction signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P14923

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only