Product Description

Catenin delta 1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66235-50, MB66235-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regμlatory domain containing mμltiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function . Catenin δ-1 fμlfills critical roles in the regμlation of cell-cell adhesion as it regμlates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion . Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion . Actin dynamics are also regμlated by catenin δ-1, which modμlates RhoA, Rac, and cdc42 proteins . Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregμlarly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: KIAA0384, Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas)

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Catenin delta 1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Catenin delta 1 protein.

Molecular Weight: ~ 95, 105 kDa

Pathway: Adherens Junction signaling, Wntβ catenin signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60716

Product: Mouse IgG. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only