Product Description

Cathepsin A 20k (M327) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS9322-50, BS9322-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellμlar metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypepidase, exists in a high molecμlar weight lysosomal complex with β-galactosidase (β-Gal) and α-neuraminidase (Neu1). Cathepsin A functions to protect β-Gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in β-Gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resμlting from the β-Gal and Neu1 deficiencies.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB

Alternate Names: Lysosomal protective protein, Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective protein cathepsin A, PPCA, Protective protein for beta-galactosidase, Lysosomal protective protein 32 kDa chain, Lysosomal protective protein 20 kDa chain, CTSA, PPGB

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to amino acids 327-380 of Human Cathepsin A.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cathepsin A 20k (M327) polyclonal antibody detects endogenous levels of Cathepsin A 20k protein.

Molecular Weight: ~ 20 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10619

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only