Cathepsin B Polyclonal Antibody - BT-AP01236

Cathepsin B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP01236-20, BT-AP01236-50, BT-AP01236-100

Citations, Manuals and MSDS Available upon request.

Background: CTSB encodes a member of the C1 family of peptidases. Alternative splicing of CTSB results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein (cathepsin B) has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of CTSB have been identified.

Research Areas: Others

Target Protein: CTSB

Applications: WB, IHC-p, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Cathepsin B Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 37822

UniProt Accession: Human: P07858; Mouse: P10605; Rat: P00787

Synonyms: CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1

GeneID: Human: 1508; Mouse: 13030

Research Use Only