Cathepsin C HC Polyclonal Antibody-BS62562

Cathepsin C HC Polyclonal Antibody

Catalogue Numbers: BS62562-50, BS62562-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P53634

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB:1:500~1:1000

Background: Cathepsin C, known also as dipeptidyl aminopeptidase I (DPPI), is a tetrameric lysosomal cysteine peptidase belonging to the papain family. Cathepsin C is involved in intracellular protein degradation and the processing of protein precursors, where it participates in cell growth, neuraminidase activation, and platelet factor XIII activation. Cathepsin C is largely related to other lysosomal cysteine proteinases, including cathepsin B, H and L . Enzymatically, Cathepsin C is capable of sequentially removing dipeptides from the amino terminus, and it requires halide ions, namely chloride ions, and thiols for complete enzymatic activity. Protein levels of Cathepsin C are detected in a variety of tissues, and it is most highly expressed in spleen, kidney, cytotoxic lymphocytes and myeloid cells, where it localizes to the secretory granule compartment. Cathepsin C is initially synthesized as a proenzyme that is rapidly processed to generate two distinct chains that function together as the mature form of the enzyme.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cathepsin C HC polyclonal antibody detects endogenous levels of Cathepsin C HC protein.

Extra Notes: Western blot (WB) analysis of Cathepsin C HC polyclonal antibody at 1:500 dilution
LaneA:H9C2 whole cell lysate
LaneB:PC3 whole cell lysate

Bioworld Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Dipeptidyl peptidase 1; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase; CPPI

Immunogen: Synthetic peptide, corresponding to Human Cathepsin C HC.

Conjugate: Unconjugated

Modification: Unmodified