Product Description

Cathepsin W Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62560-50, BS62560-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, and are phylogenetically distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81-119 bp. Cathepsin W protein is expressed specifically in CD8+ T-lymphocyte. The expression of cathepsin W first occurs during the differentiation of thyrocytes to CD8+ T-lymphocytes, just as the thymocytes cease expression of CD4+ receptors. In transfected Cos-7 and Hela cells, cathepsin W localizes within the rough endoplasmic reticμlum. Cathepsin W contains a unique 21-amino acid peptide insertion between the active site histidine and asparagine residues, in addition to a distictive 8-amino acid carboxy- terminal extension. An extended loop structure in the second or β-sheet domain and an additional disμlfide bind are two of several signature features of cathepsin W. Other features of cathepsin W include an additional cysteine, an S2 pocket and an additional residue. Cathepsin W may exist as a dimer with each monomer forming a disμlfide bond.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Cathepsin W, Lymphopain, CTSW

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human Cathepsin W.

Dilution: WB:1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cathepsin W polyclonal antibody detects endogenous levels of Cathepsin W protein.

Molecular Weight: ~ 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P56202

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only