Product Description

CB2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS72043-50, BS72043-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P34972

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:100

Background: The cannabinoid receptors (CB1 and CB2) are G protein-coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids.CB1 is expressed in brain tissue and, in low levels, in testis. CB2 is expressed only by cells of the immune system. The cannabinoid receptors mediate most of the cannabinoid-induced responses in a dose-dependent, stereoselective manner. This response system is thought to be involved in specific brain functions, such as nociception, control of movement, memory and neuroendocrine regulation, as well as having a possible role in brain development. In addition, CB1 may mediate the addictive behavior involved with the use of psychoactive cannabinoids, such as THC in marijuana.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CB2 polyclonal antibody detects endogenous levels of CB2 protein.

Bioworld Molecular Weight: 45kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extracts of various cell lines, using CNR2 antibody at 1:3000 dilution.

Alternative Name: Cannabinoid receptor 2; CB-2; CB2; hCB2; CX5; CNR2; CB2A; CB2B

Immunogen: A synthetic peptide of human CNR2

Conjugate: Unconjugated

Modification: Unmodified