Product Description

CBFA2T2 Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: BS8660-50, BS8660-100

Swiss-Prot: O43439

Host: Rabbit

CBFA2T2 Polyclonal Antibody-BS8660

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat

Applications: WB, IF

All Applications: WB 1:500 - 1:2000
IF 1:50 - 1:100

Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8; 21)(q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CBFA2T2 polyclonal antibody detects endogenous levels of CBFA2T2 protein.

Bioworld Molecular Weight: ~ 67kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of various cell lines, using CBFA2T2 antibody., Immunofluorescence analysis of U20S cell using CBFA2T2 antibody.

Alternative Name: Protein CBFA2T2; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85; CBFA2T2; EHT, MTGR1

Immunogen: Recombinant full length Human CBFA2T2.

Modification: Unmodified

Conjugate: Unconjugated