CBL Polyclonal Antibody - E-AB-63260

CBL Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-63260-60, E-AB-63260-120, E-AB-63260-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CBL

Target Synonym: C-CBL; CBL2; FRA11B; NSLL; RNF55; CBL; c-Cbl

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P22681

Background: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human CBL (NP_005179.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: IHC 1:50-1:100 IF 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only