Product Description

CBP (E1528) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2544-50, BS2544-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cyclic AMP-regμlated gene expression frequently involves a DNA element designated the cAMP-regμlated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a resμlt of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation resμlts in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecμlar weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: CREB-binding protein, CREBBP, CBP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1500-1540 of Human CBP.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CBP (E1528) polyclonal antibody detects endogenous levels of CBP protein.

Molecular Weight: ~ 265 kDa

Pathway: Nuclear Receptor Signaling, Hypoxia Signaling, Insμlin &Glucose Signaling, Contribution of Soluble Factors to EMT, Epigenetic Writers and Erasers of Histone H3, Epigenetic Writers and Erasers of Histones H2A H2B and H4,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q92793

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only