Product Description

CBX3 Monoclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-22145-60, E-AB-22145-120, E-AB-22145-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CBX3

Target Synonym: CBX 3; CBX3; CBX3; Chromobox homolog 3 (HP1 gamma homolog; Drosophila); Chromobox homolog 3; Chromobox protein homolog 3; GAMMA; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; HP1 gamma; HP1 gamma homolog; HP1Hs gamma; Modifier 2 protein

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC-p

Isotype: IgG

Clonality: Monoclonal

Clone No.: Clone:6A4

UNIProt ID: Q13185

Background: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks.

Concentration: 1 mg/mL

Immunogen: Recombinant Protein of HP-1γ

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification Method: Protein A purification

Dilution: WB 1:500-2000, IHC 1:50-300

Observed MW: 24kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only