Product Description

CBX8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7971-50, BS7971-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Polycomb group (PcG) proteins form mμltiprotein complexes and play a role in gene silencing and Hox gene regμlation by altering chromatin structure during transcription. The PcG protein MPc3 is also known as CBX8, PC3, HPc3 or RC1. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. However, MPc3 has only been shown to bind RING1 in vivo with covalently modified forms of RING1. MPc3 also interacts with the carboxy-terminus of AF9, a transcriptional activator implicated in the development of acute lukemias. MPc3 acts as a long range transcriptional silencer when targeted to a reporter gene by a heterologous DNA-binding domain. The human MPc3 gene maps to chromosome 17q25.3 and encodes a 389 amino acid protein.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Cbx8, CBX8_HUMAN, Chromobox Homolog 8 (Drosophila Pc Class), Chromobox Homolog 8 (Pc Class Homolog, Drosophila), Chromobox Homolog 8, Chromobox protein homolog 8, hPc3, Pc Class 3 Homolog (Drosophila), Pc Class 3 Homolog, Pc3, Polycomb 3, Polycomb 3 homolog, RC1, Rectachrome 1,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human CBX8.

Dilution: WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CBX8 polyclonal antibody detects endogenous levels of CBX8 protein.

Molecular Weight: ~ 50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9HC52

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only