Product Description

CCL11 Polyclonal Antibody

Catalogue Numbers: BS60485-50, BS60485-100

Sizes: 50µl, 100µl

Alternative Name: Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; CCL11; SCYA11

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P51671

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Eotaxin (also designated eotaxin-1) is a member of the C-C or ∫ family of chemokines which is characterized by a pair of adjacent cysteine residues. Eotaxin was first purified from the bronchoalveolar lavage fluid of guinea pigs challenged with an aerosol allergen, and serves as a potent chemoattractant for eosinophils. Eosinophilia is a prominent feature of several allergic conditions and is thought to be a central event in maladies such as bronchial asthma, dermatitis, conjunctivitis and possibly inflammatory bowel disease. The cognate eotaxin receptor has been identified. Originally described as mouse orphan receptor (MIP-1a receptor-like 2), CKR-3 has been shown to not only serve as the high affinity receptor for eotaxin, but also for RANTES and MCP-3. CKR-3 is expressed on the cell surface of primary eosinophils and does not bind to other members of the C-C or C-X-C family of chemokines. CKR-3 also serves as a co-receptor for a restricted subset of viruses.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CCL11 polyclonal antibody detects endogenous levels of CCL11 protein.

Bioworld Molecular Weight: ~ 11 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CCL11 polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human CCL11.

Conjugate: Unconjugated

Modification: Unmodified