Product Description

CCL22 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA22889-50, RA22889-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC (3-69), MDC (5-69) and MDC (7-69) seem not be active., online information:CCL22 entry, PTM:The N-terminal processed forms MDC (3-69), MDC (5-69) and MDC (7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes., similarity:Belongs to the intercrine beta (chemokine CC) family., tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the eptdermis and dermis.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: C-C motif chemokine 22 (CC chemokine STCP-1;MDC (1-69);Macrophage-derived chemokine;Small-inducible cytokine A22;Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC (3-69), MDC (5-69), MDC (7-69)]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Storage: -20°C/1 year

Human Gene ID: 6367

Human SwissProt Number: O00626

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only