CD10 Monoclonal Antibody (5B8) - RA10904

CD10 Monoclonal Antibody (5B8) Size: 50μL, 100μL Catalogue Numbers: RA10904-50, RA10904-100 Citations, Manuals and MSDS Available upon request. Background: membrane metalloendopeptidase (MME) Homo sapiens This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this Condition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol. Storage Instructions: -20°C/1 year Applications: IF/ICC; IHC-p Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 4311 SWISS: P08473 Source: Mouse Research Use Only