CD10 Rabbit pAb - EA321

CD10 Rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: EA321-50, EA321-100

Citations, Manuals and MSDS Available upon request.

Background: CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.

Alternate Name: CALLA, Enkephalinase, MME, NEP, Neutral endopeptidase antibody

Source: Rabbit

Applications: IHC

Dilution: IHC 1:200-500

Reactivity: Human, Rat, Mouse

Immunogen: Recombinant Protein

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Polyclonal

Isotype: IgG

Concentration: 1mg/mL

Observed Band (KD): 85kDa

Human Gene ID: 4311

Human SWISS Prot NO: P08473

Subcellular Location: Cell membrane

Research Use Only