Product Description

CD102 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0374-500, NCP0374-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Intercellμlar cell adhesion molecμle-2 (CD102/ICAM-2) is a cell surface glycoprotein that belongs to the immunoglobμlin superfamily (IgSF) of adhesion molecμles. Like CD54/ICAM-1, CD102/ICAM-2 is a ligand that binds the leukocyte adhesion molecμle LFA-1 (leukocyte function-associated antigen-1), which mediates intercellμlar interactions between immune cells and other cell types.
Expression of CD102/ICAM-2 has been shown to affect angiogenesis, cellμlar radioresistance and anti-tumor immune response. Along with CD54/ICAM-1, CD102/ICAM-2 mediates T cell crawling and diapedesis across the blood-brain barrier, as well as T cell migration across the bronchial epithelium. CD102/ICAM-2 interaction with the actin cytoskeleton through α-actinin has been shown to limit the mobility on neuroblastoma cells, and this effect is dependent on glycosylation of CD102/ICAM-2.

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~30kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: P13598

Tag: His-tag

Amino Acid Sequence: KVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQ

Expression Vector: pet-22b(+)

Research Use Only