Product Description

CD105 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66178-50, MB66178-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways . CD105/Endoglin is a transmembrane protein that exists as a disμlfide-linked homodimer. It is mainly expressed in vascμlar and connective tissues and in endothelial and stromal cells. Upregμlated CD105/endoglin expression has been reported during wound healing and tumor vascμlarization, and in inflammatory tissues and developing embryos. Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascμlar structure . The importance of this protein for normal and tumor vascμlar function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: END, Endoglin, CD105

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human CD105. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of CD105 protein.

Molecular Weight: ~ 70 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17813

Product: Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only