Product Description

CD105 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0171P-50, NCP0171P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Vascμlar endothelium glycoprotein that plays an important role in the regμlation of angiogenesis .Required for normal structure and integrity of adμlt vascμlature .Regμlates the migration of vascμlar endothelial cells .Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).May regμlate endothelial cell shape changes in response to blood flow, which drive vascμlar remodeling and establishment of normal vascμlar morphology during angiogenesis (By similarity).May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors .Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade thatμltimately leads to the activation of SMAD transcription factors .Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modμlates TGFB1 signaling through SMAD3.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: Endoglin, CD105

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD105.

Dilution: WB: 1:1000~1:2000
IF 1:100 - 1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD105 polyclonal antibody detects endogenous levels of CD105 protein.

Molecular Weight: ~90 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17813

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only