Product Description

CD105 Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Catalogue Numbers: NCP0171P-50, NCP0171P-100

Sizes: 50µl, 100µl

Swiss-Prot: P17813

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

Background: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis .Required for normal structure and integrity of adult vasculature .Regulates the migration of vascular endothelial cells .Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors .Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors .Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD105 polyclonal antibody detects endogenous levels of CD105 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CD105 polyclonal antibody at 1:1000 dilution
Lane 1: MCF-7 cell membrane lysate (20ug)
Lane 2: A549 cell membrane lysate (30ug), Western blot (WB) analysis of CD105 polyclonal antibody at 1:1000 dilution
Lane 1: A549 whole cell lysate (40ug)
Lane 2: CT-26 whole cell lysate (40ug)

Bioworld Molecular Weight: ~90 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Endoglin; CD105

Immunogen: Recombinant protein of human CD105.

Conjugate: Unconjugated

Modification: Unmodified