Product Description

CD105 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0171-500, NCP0171-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. CD105/Endoglin is a transmembrane protein that exists as a disμlfide-linked homodimer. It is mainly expressed in vascμlar and connective tissues and in endothelial and stromal cells. Upregμlated CD105/endoglin expression has been reported during wound healing and tumor vascμlarization, and in inflammatory tissues and developing embryos. Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascμlar structure. The importance of this protein for normal and tumor vascμlar function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~62kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: P17813

Tag: His-tag

Amino Acid Sequence: GAAACCGTGCATTGCGATCTGCAGCCGGTTGGTCCGGAACGCGGTGAAGTTACCTATACCACCAGCCAGGTTAGTAAAGGCTGTGTTGCACAGGCACCGAATGCCATTCTGGAAGTGCATGTTCTGTTCCTGGAATTCCCGACCGGTCCGAGTCAGCTGGAACTGACCCTGCAGGCCAGCAAACAGAATGGCACCTGGCCGCGCGAAGTTCTGCTGGTTCTGAGTGTTAATAGCAGCGTGTTCCTGCATCTGCAGGCCCTGGGCATTCCGCTGCATCTGGCATATAATAGTAGTCTGGTTACCTTCCAGGAACCGCCGGGTGTTAATACCACCGAACTGCCGAGCTTCCCGAAAACACAAATTCTGGAATGGGCAGCCGAACGTGGCCCGATTACCAGCGCCGCAGAACTGAATGATCCGCAGAGCATTCTGCTGCGCCTGGGCCAGGCCCAGGGCAGCTTAAGCTTCTGCATGCTGGAAGCAAGTCAGGATATGGGTCGCACCCTGGAATGGCGCCCGCGCACACCTGCACTGGTGCGTGGTTGCCATCTGGAAGGTGTTGCCGGCCATAAAGAAGCACATATTCTGCGCGTGCTGCCGGGTCATAGCGCAGGCCCTCGCACCGTTACCGTGAAAGTTGAACTGAGTTGTGCACCGGGTGATCTGGATGCCGTTCTGATTCTGCAGGGTCCGCCGTATGTGAGTTGGCTGATTGATGCAAATCATAATATGCAGATCTGGACCACCGGTGAATATAGCTTCAAAATCTTCCCGGAAAAAAATATTCGTGGCTTCAAACTGCCGGATACCCCGCAGGGTCTGCTGGGTGAAGCCCGTATGCTGAATGCAAGCATTGTTGCAAGCTTCGTTGAACTGCCGCTGGCAAGCATTGTGAGTCTGCATGCAAGCAGCTGCGGTGGTCGTCTGCAGACCAGCCCGGCCCCTATTCAGACCACCCCGCCGAAAGATACCTGCAGTCCGGAACTGCTGATGAGCCTGATTCAGACCAAATGTGCAGATGATGCCATGACCCTGGTTCTGAAAAAAGAACTGGTTGCCCATCTGAAATGTACCATTACCGGCCTGACCTTCTGGGATCCGAGCTGTGAAGCAGAAGATCGTGGCGATAAATTCGTTCTGCGCAGTGCATATAGCAGTTGTGGCATGCAGGTTAGTGCCAGTATGATTAGTAATGAAGCCGTGGTTAATATTCTGAGCAGCAGTAGCCCGCAGCGCAAAAAAGTGCATTGCCTGAATATGGATAGTCTGAGCTTCCAGCTGGGTCTGTATCTGAGTCCGCACTTCCTGCAGGCCAGTAATACCATTGAACCGGGCCAGCAGAGCTTCGTTCAGGTGCGCGTTAGCCCGAGTGTGAGCGAATTCCTGCTGCAGCTGGATAGTTGCCATCTGGATCTGGGCCCGGAAGGTGGTACCGTTGAACTGATTCAGGGCCGCGCCGCCAAAGGTAATTGTGTGAGTCTGCTGAGTCCGAGCCCGGAAGGTGATCCGCGCTTCAGCTTCCTGCTGCACTTCTATACCGTGCCGATTCCGAAAACCGGTACCCTGAGCTGCACCGTGGCCCTGCGTCCGAAAACCGGCAGTCAGGATCAGGAAGTTCATCGTACCGTGTTCATGCGCCTGAATATTATTAGTCCGGATCTGAGTGGTTGTACCAGTAAAGGC

Expression Vector: pet-22b(+)

Research Use Only