CD105 Recombinant Protein - NCP0171

CD105 Recombinant Protein

Catalogue Number: NCP0171-500, NCP0171-1000

Sizes: 500ug, 1mg

Swiss-Prot: P17813

Host: E.coli

Tag: His-tag

AA Sequence: GAAACCGTGCATTGCGATCTGCAGCCGGTTGGTCCGGAACGCGGTGAAGTTACCTATACCACCAGCCAGGTTAGTAAAGGCTGTGTTGCACAGGCACCGAATGCCATTCTGGAAGTGCATGTTCTGTTCCTGGAATTCCCGACCGGTCCGAGTCAGCTGGAACTGACCCTGCAGGCCAGCAAACAGAATGGCACCTGGCCGCGCGAAGTTCTGCTGGTTCTGAGTGTTAATAGCAGCGTGTTCCTGCATCTGCAGGCCCTGGGCATTCCGCTGCATCTGGCATATAATAGTAGTCTGGTTACCTTCCAGGAACCGCCGGGTGTTAATACCACCGAACTGCCGAGCTTCCCGAAAACACAAATTCTGGAATGGGCAGCCGAACGTGGCCCGATTACCAGCGCCGCAGAACTGAATGATCCGCAGAGCATTCTGCTGCGCCTGGGCCAGGCCCAGGGCAGCTTAAGCTTCTGCATGCTGGAAGCAAGTCAGGATATGGGTCGCACCCTGGAATGGCGCCCGCGCACACCTGCACTGGTGCGTGGTTGCCATCTGGAAGGTGTTGCCGGCCATAAAGAAGCACATATTCTGCGCGTGCTGCCGGGTCATAGCGCAGGCCCTCGCACCGTTACCGTGAAAGTTGAACTGAGTTGTGCACCGGGTGATCTGGATGCCGTTCTGATTCTGCAGGGTCCGCCGTATGTGAGTTGGCTGATTGATGCAAATCATAATATGCAGATCTGGACCACCGGTGAATATAGCTTCAAAATCTTCCCGGAAAAAAATATTCGTGGCTTCAAACTGCCGGATACCCCGCAGGGTCTGCTGGGTGAAGCCCGTATGCTGAATGCAAGCATTGTTGCAAGCTTCGTTGAACTGCCGCTGGCAAGCATTGTGAGTCTGCATGCAAGCAGCTGCGGTGGTCGTCTGCAGACCAGCCCGGCCCCTATTCAGACCACCCCGCCGAAAGATACCTGCAGTCCGGAACTGCTGATGAGCCTGATTCAGACCAAATGTGCAGATGATGCCATGACCCTGGTTCTGAAAAAAGAACTGGTTGCCCATCTGAAATGTACCATTACCGGCCTGACCTTCTGGGATCCGAGCTGTGAAGCAGAAGATCGTGGCGATAAATTCGTTCTGCGCAGTGCATATAGCAGTTGTGGCATGCAGGTTAGTGCCAGTATGATTAGTAATGAAGCCGTGGTTAATATTCTGAGCAGCAGTAGCCCGCAGCGCAAAAAAGTGCATTGCCTGAATATGGATAGTCTGAGCTTCCAGCTGGGTCTGTATCTGAGTCCGCACTTCCTGCAGGCCAGTAATACCATTGAACCGGGCCAGCAGAGCTTCGTTCAGGTGCGCGTTAGCCCGAGTGTGAGCGAATTCCTGCTGCAGCTGGATAGTTGCCATCTGGATCTGGGCCCGGAAGGTGGTACCGTTGAACTGATTCAGGGCCGCGCCGCCAAAGGTAATTGTGTGAGTCTGCTGAGTCCGAGCCCGGAAGGTGATCCGCGCTTCAGCTTCCTGCTGCACTTCTATACCGTGCCGATTCCGAAAACCGGTACCCTGAGCTGCACCGTGGCCCTGCGTCCGAAAACCGGCAGTCAGGATCAGGAAGTTCATCGTACCGTGTTCATGCGCCTGAATATTATTAGTCCGGATCTGAGTGGTTGTACCAGTAAAGGC

Restriction Sites: NdeI-XhoI

Background: CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated CD105/endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.

Soluble: PBS, 4M Urea, PH7.4

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Expression Vector: pet-22b(+)

BioWorld Molecular Weight: ~62kDa

Notes: For research use only, not for use in diagnostic procedure.