Product Description

CD109 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0172-500, NCP0172-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that belongs to the alpha2-macroglobμlin family of thioester containing proteins. CD109 is associated with TGF-beta receptor I (TbRI) and inhibits TGF-beta signaling. Cleavage of CD109 at its Furin cleavage site resμlts in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling. CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. Elevated CD109 expression has been considered a diagnostic/prognostic marker for several types of cancers.

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~36kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: Q6YHK3

Tag: His-tag

Amino Acid Sequence: CTGAGCAGTGTGGGCAGCCCGAAAGCAAAAGAAGCACTGAATATGCTGACCTGGCGCGCAGAACAGGAAGGTGGCATGCAGTTCTGGGTGAGCAGTGAAAGCAAACTGAGCGATAGTTGGCAGCCGCGTAGCCTGGATATTGAAGTTGCAGCCTATGCACTGCTGAGTCACTTCCTGCAGTTCCAGACCAGCGAAGGTATTCCGATTATGCGTTGGCTGAGCCGTCAGCGCAATAGTCTGGGCGGCTTCGCAAGTACCCAGGATACCACCGTGGCCCTGAAAGCCCTGAGCGAATTCGCAGCACTGATGAATACCGAACGCACCAATATTCAGGTTACCGTGACCGGCCCGAGTAGCCCGAGCCCTGTGAAATTCCTGATTGATACCCATAATCGTCTGCTGCTGCAGACCGCAGAACTGGCAGTTGTGCAGCCGACCGCCGTTAATATTAGTGCCAATGGCTTCGGCTTCGCAATCTGTCAGCTGAATGTGGTGTATAATGTGAAAGCCAGTGGTAGCAGCCGCCGCCGCCGCAGCATTCAGAATCAGGAAGCATTCGATCTGGATGTGGCCGTTAAAGAAAATAAAGATGATCTGAATCACGTGGATCTGAATGTGTGTACCAGCTTCAGTGGCCCGGGTCGCAGTGGCATGGCACTGATGGAAGTTAATCTGCTGAGCGGCTTCATGGTTCCGAGTGAAGCAATTAGTCTGAGCGAAACCGTGAAAAAAGTTGAATATGATCATGGTAAGCTGAATCTGTATCTGGATAGTGTTAATGAAACACAATTCTGTGTGAATATCCCGGCAGTGCGTAACTTCAAAGTTAGCAATACCCAGGATGCAAGCGTTAGCATTGTGGATTATTATGAACCGCGCCGTCAGGCCGTGCGTAGCTATAATAGCGAAGTGAAACTGAGTAGTTGTGATCTGTGCAGTGATGTGCAGGGTTGTCGTCCGTGCGAAGATGGTGCA

Expression Vector: pet-22b(+)

Research Use Only