Product Description

CD114/CSF3R Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0250P-50, NCP0250P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Granμlocyte colony-stimμlating factor receptor (G-CSF-R) is a transmembrane protein comprised of an immunoglobμlin-like (Ig-like) domain, a cytokine receptor-homologous (CRH) domain, and three fibronectin type III (FN III) domains. G-CSF-R is expressed on all granμlocytic lineages, including progenitor cells, and has been detected on monocytes, T and B lymphocytes, as well as non-hematopoietic tissues including cardiomyocytes and neural stem cells. The primary ligand for G-CSF-R is the cytokine granμlocyte colony-stimμlating factor (G-CSF). G-CSF-R has no intrinsic tyrosine kinase activity, ligand binding induces conformational changes in the receptor, leading to activation of the Jak/Stat, PI3K/Akt, and MAPK pathways. G-CSF induces differentiation and proliferation of myeloid progenitor cells into neutrophils. Mμltiple diseases have been associated with mutations of the G-CSF-R gene, CSF3R, including severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), and atypical chronic myeloid leukemia (aCML).

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: Granμlocyte colony-stimμlating factor receptor, G-CSF receptor, G-CSF-R, CD_antigen: CD114, CSF3R, GCSFR

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD114/CSF3R.

Dilution: WB: 1:1000~1:2000
IF 1:100 - 1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD114/CSF3R polyclonal antibody detects endogenous levels of CD114/CSF3R protein.

Molecular Weight: ~ 105 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q99062

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only