Product Description

CD11a Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90209-50, BS90209-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P20701(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF, IHC, IP, , FC

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CD11a polyclonal antibody detects endogenous levels of CD11a protein.

Bioworld Molecular Weight: 180 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CD11a on Jurkat cell lysates using anti-CD11a antibody at 1/1,000 dilution., ICC staining CD11a in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: LFA-1A, ITGAL, CD11A, Lymphocyte function associated antigen, type 1, alpha subunit, Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide, Antigen CD11A, CD 11a, CD11 antigen-like family member A, CD11a, CD11a antigen, Integrin Alpha L, Integrin alpha-L, Integrin gene promoter, Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide), ITAL, Itgal, ITGAL protein, Leukocyte adhesion glycoprotein LFA 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain, Leukocyte function associated molecule 1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, LFA 1 alpha (LFA1A), LFA 1 alpha, LFA 1, LFA 1A, LFA-1A, LFA1A, Ly15, Ly21, Lymphocyte function associated antigen 1, Lymphocyte Function Associated Antigen Type 1 alpha, lymphocyte function-associated antigen 1, alpha polypeptide, p180,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified