Product Description

CD126 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0257P-50, NCP0257P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The IL-6 receptor is a heterodimeric complex that consists of a ligand-binding IL-6 receptor α (IL-6Rα) subunit and a signaling component, gp130. Binding of IL-6 to IL-6Rα resμlts in receptor dimerization with gp130 and subsequent STAT3 activation. IL-6Rα is cleaved from the cell surface by ADAM17 (1, 2). In humans, soluble IL-6Rα is also generated via alternatively spliced mRNA. Soluble IL-6Rα binds to IL-6 and can stimμlate signaling via membrane bound gp130 in a process known as “trans-signaling”. It is through trans-signaling that IL-6 stimμlates cells that do not express membrane bound IL-6Rα.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: IF

Alternate Names: Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80, gp80, Soluble interleukin-6 receptor subunit alpha, CD126, IL6R

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD126.

Dilution: IF: 1:100~1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD126 polyclonal antibody detects endogenous levels of CD126 protein.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08887

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only