Product Description

CD135 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ16217-50, BZ16217-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a class III receptor tyrosine kinase that regμlates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellμlar domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates mμltiple cytoplasmic effector molecμles in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that resμlt in the constitutive activation of this receptor resμlt in acute myeloid leukemia and acute lymphoblastic leukemia.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: FLT3, CD135, FLK2, STK1, Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD antigen CD135

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human FLT3. AA range:451-500

Dilution: WB: 1/500-1/1000 ELISA: 1/10000

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: Calcμlated MW: 113 kDa, Observed MW: 110 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P36888

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only