Product Description

CD135 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0262P-50, NCP0262P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: FMS-related tyrosine kinase 3 (FLT3, also called FLK2), is a member of the Type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system. FLT3 is activated after binding with its ligand FL, which resμlts in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream substrates. The p85 subunit of PI3 kinase, SHP2, GRB2, and Shc have all been reported to associate with FLT3 after FL stimμlation. Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regμlation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Receptor-type tyrosine-protein kinase FLT3, EC:2.7.10.1, FL cytokine receptor, Fetal liver kinase-2 (FLK-2), Fms-like tyrosine kinase 3 (FLT-3), Stem cell tyrosine kinase 1 (STK-1), CD135, FLT3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human CD135.

Dilution: WB: 1:2000~1:5000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD135 polyclonal antibody detects endogenous levels of CD135 protein.

Molecular Weight: ~112 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P36888

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only