Product Description

CD143 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0268P-50, NCP0268P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circμlating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regμlation of blood pressure, electrolyte homeostasis or synaptic plasticity Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates .Plays a major role in the angiotensin-renin system that regμlates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resμlting in an increase of the vasoconstrictor activity of angiotensin .Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response.Acts as a regμlator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins .Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) . Acts as a regμlator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin (By similarity).Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (By similarity).Also acts as a regμlator of hematopoietic stem cell differentiation by mediating degradation of hemoregμlatory peptide N-acetyl-SDKP (AcSDKP).Acts as a regμlator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing plaque formation.Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin-8 and Cholecystokinin-5) and Gonadoliberin-1 (both maturation and degradation) hormones.Degradation of hemoregμlatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C-terminal catalytic region.

Category: Primary Antibody

Reactivity: Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase, Kininase II, CD143, Angiotensin-converting enzyme, soluble form

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human CD143.

Dilution: WB: 1:1000~1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD143 polyclonal antibody detects endogenous levels of CD143 protein.

Molecular Weight: ~ 170 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P12821

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only