Product Description

CD146/MCAM Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-92375-60, E-AB-92375-120, E-AB-92375-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD146/MCAM

Target Synonym: MCAM; CD146; MUC18; cell surface glycoprotein MUC18

Research Areas: Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P43121

Background: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human CD146/MCAM

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 57kDa/71kDa

Observed MW: 120KDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only