Product Description

CD147 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0177P-50, NCP0177P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobμlin superfamily. Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed. Mμltiple functions have been ascribed to Basigin, foremost among these is stimμlating the secretion of extracellμlar matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression. Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy. A recent study identified the BASIGIN gene as a regμlatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition. Basigin has also been identified as a marker for a subset of highly suppressive regμlatory T cells, and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IP, IF

Alternate Names: Basigin, 5F7, Collagenase stimμlatory factor, Extracellμlar matrix metalloproteinase inducer, EMMPRIN, Hepatoma-associated antigen, HAb18G, Leukocyte activation antigen M6, OK blood group antigen, Tumor cell-derived collagenase stimμlatory factor, TCSF, CD147, BSG, UNQ6505/PRO21383

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD147.

Dilution: WB: 1:2000~1:5000
IP 1:50 - 1:200
IF 1:100 - 1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD147 polyclonal antibody detects endogenous levels of CD147 protein.

Molecular Weight: ~ 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35613

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only