Product Description

CD155 Polyclonal Antibody

Catalogue Numbers: NCP0274P-50, NCP0274P-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: P15151

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1:5000~1:10000

Background: Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells. Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells. Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma. In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD155 polyclonal antibody detects endogenous levels of CD155 protein.

Extra Notes: Western blot (WB) analysis of CD155 polyclonal antibody at 1:10000 dilution
Lane1:CT-26 whole cell lysate(30ug)
Lane2:HepG2 whole cell lysate(10ug)
Lane3:A549 whole cell lysate(10ug)

Bioworld Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Poliovirus receptor; Nectin-like protein 5 (NECL-5); CD155; PVR; PVS

Immunogen: Synthetic peptide, corresponding to Human CD155.

Conjugate: Unconjugated

Modification: Unmodified