CD155 Recombinant Protein - NCP0274

CD155 Recombinant Protein

Catalogue Number: NCP0274-500, NCP0274-1000

Sizes: 500ug, 1mg

Swiss-Prot: P15151

Host: E.coli

Tag: His-tag

AA Sequence: TGGCCTCCTCCGGGTACCGGTGATGTTGTGGTTCAGGCACCGACCCAGGTGCCGGGCTTCCTGGGTGATAGTGTTACCCTGCCGTGTTATCTGCAGGTTCCGAATATGGAAGTGACCCATGTTAGTCAGCTGACCTGGGCACGCCATGGTGAAAGCGGTAGCATGGCCGTGTTCCATCAGACCCAGGGTCCGAGTTATAGCGAAAGCAAACGCCTGGAATTCGTGGCAGCCCGCCTGGGTGCAGAACTGCGTAATGCCAGTCTGCGCATGTTCGGCCTGCGCGTGGAAGATGAAGGCAATTATACCTGCCTGTTCGTTACCTTCCCGCAGGGTAGTCGTAGCGTGGATATCTGGCTGCGCGTGCTGGCCAAACCGCAGAATACCGCCGAAGTTCAGAAAGTGCAGCTGACCGGTGAACCGGTGCCGATGGCACGCTGTGTGAGCACCGGTGGTCGTCCGCCGGCACAGATTACCTGGCATAGTGATCTGGGTGGTATGCCGAATACCAGCCAGGTGCCGGGCTTCTTAAGTGGTACCGTGACCGTGACCAGTCTGTGGATTCTGGTGCCGAGCAGTCAGGTTGATGGCAAAAATGTTACCTGTAAAGTTGAACATGAGAGCTTCGAAAAACCGCAGCTGCTGACCGTGAATCTGACCGTGTATTATCCGCCGGAAGTTAGCATTAGCGGCTATGATAATAATTGGTATCTGGGCCAGAATGAAGCCACCCTGACCTGCGATGCCCGCAGTAATCCGGAACCGACCGGTTATAATTGGAGTACCACCATGGGCCCGCTGCCGCCGTTCGCAGTGGCACAAGGTGCACAGCTGCTGATTCGCCCGGTGGATAAACCGATTAATACCACCCTGATCTGTAATGTTACCAATGCACTGGGCGCACGTCAGGCCGAACTGACCGTTCAGGTTAAAGAAGGTCCGCCGAGTGAACATAGTGGTATTAGCCGTAAT

Restriction Sites: NdeI-XhoI

Background: Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells. Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells. Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma. In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity.

Soluble: PBS, 4M Urea, PH7.4

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Expression Vector: pet-22b(+)

BioWorld Molecular Weight: ~36kDa

Notes: For research use only, not for use in diagnostic procedure.