Product Description

CD155 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0274-500, NCP0274-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Poliovirus receptor (PVR, CD155) is an immunoglobμlin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regμlate integrin clustering and focal contact formation at the leading edge of migrating cells. Research studies demonstrate that PVR and nectin-3 regμlate contact inhibition during cell motility and proliferation in transformed 3T3 cells. Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma. In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity.

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~36kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: P15151

Tag: His-tag

Amino Acid Sequence: TGGCCTCCTCCGGGTACCGGTGATGTTGTGGTTCAGGCACCGACCCAGGTGCCGGGCTTCCTGGGTGATAGTGTTACCCTGCCGTGTTATCTGCAGGTTCCGAATATGGAAGTGACCCATGTTAGTCAGCTGACCTGGGCACGCCATGGTGAAAGCGGTAGCATGGCCGTGTTCCATCAGACCCAGGGTCCGAGTTATAGCGAAAGCAAACGCCTGGAATTCGTGGCAGCCCGCCTGGGTGCAGAACTGCGTAATGCCAGTCTGCGCATGTTCGGCCTGCGCGTGGAAGATGAAGGCAATTATACCTGCCTGTTCGTTACCTTCCCGCAGGGTAGTCGTAGCGTGGATATCTGGCTGCGCGTGCTGGCCAAACCGCAGAATACCGCCGAAGTTCAGAAAGTGCAGCTGACCGGTGAACCGGTGCCGATGGCACGCTGTGTGAGCACCGGTGGTCGTCCGCCGGCACAGATTACCTGGCATAGTGATCTGGGTGGTATGCCGAATACCAGCCAGGTGCCGGGCTTCTTAAGTGGTACCGTGACCGTGACCAGTCTGTGGATTCTGGTGCCGAGCAGTCAGGTTGATGGCAAAAATGTTACCTGTAAAGTTGAACATGAGAGCTTCGAAAAACCGCAGCTGCTGACCGTGAATCTGACCGTGTATTATCCGCCGGAAGTTAGCATTAGCGGCTATGATAATAATTGGTATCTGGGCCAGAATGAAGCCACCCTGACCTGCGATGCCCGCAGTAATCCGGAACCGACCGGTTATAATTGGAGTACCACCATGGGCCCGCTGCCGCCGTTCGCAGTGGCACAAGGTGCACAGCTGCTGATTCGCCCGGTGGATAAACCGATTAATACCACCCTGATCTGTAATGTTACCAATGCACTGGGCGCACGTCAGGCCGAACTGACCGTTCAGGTTAAAGAAGGTCCGCCGAGTGAACATAGTGGTATTAGCCGTAAT

Expression Vector: pet-22b(+)

Research Use Only