CD158a Polyclonal Antibody Catalogue Numbers: NCP0282P-50, NCP0282P-100 Sizes: 50µl, 100µl Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. Swiss-Prot: P43626 Host: Rabbit Reactivity: Human, Mouse Applications: WB All Applications: WB: 1:5000~1:10000 Background: NKAT (NK-associated transcripts) gene products, known as killer immunoglobulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif). The human inhibitory natural killer cell immunoglobulin-like receptor 2DL1, also designated KIR2DL1, CL-42, NKAT1, P58.1 or CD158a long form, is a 348 amino acid type I transmembrane protein. KIR2DL1 can bind human leukocyte antigen-C (HLA-C) via both polar and hydrophobic interactions through Met 44 in a binding pocket that coordinates Lys 80 of HLA-C. Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: CD158a polyclonal antibody detects endogenous levels of CD158a protein. Extra Notes: Western blot (WB) analysis of CD158a polyclonal antibody at 1:5000 dilution Lane1:The Heart tissue lysate of Mouse(15ug) Lane2:L02 cell membrane lysate(24ug) Lane3:MCF-7 cell membrane lysate(24ug) Bioworld Molecular Weight: ~ 49 kDa Note: For research use only, not for use in diagnostic procedure. Alternative Name: Killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor; CD158a; KIR2DL1; CD158A; NKAT1 Immunogen: Recombinant protein of human CD158a. Conjugate: Unconjugated Modification: Unmodified