CD158a Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: NCP0282P-50, NCP0282P-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: NKAT (NK-associated transcripts) gene products, known as killer immunoglobμlin-like receptors or KIRs, downregμlate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecμles on target cells. This family of receptors is characterized by an extracellμlar region with two to three immunoglobμlin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif). The human inhibitory natural killer cell immunoglobμlin-like receptor 2DL1, also designated KIR2DL1, CL-42, NKAT1, P58.1 or CD158a long form, is a 348 amino acid type I transmembrane protein. KIR2DL1 can bind human leukocyte antigen-C (HLA-C) via both polar and hydrophobic interactions through Met 44 in a binding pocket that coordinates Lys 80 of HLA-C. Category: Primary Antibody Reactivity: Human, Mouse Host: Rabbit Applications: WB, IF Alternate Names: Killer cell immunoglobμlin-like receptor 2DL1, CD158 antigen-like family member A, Natural killer-associated transcript 1, NKAT-1, p58 natural killer cell receptor clones CL-42/47.11, p58 NK receptor CL-42/47.11, p58.1 MHC class-I-specific NK receptor, CD158a, KIR2DL1, CD158A, NKAT1 Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodified Immunogen: Recombinant protein of human CD158a. Dilution: WB: 1:5000~1:10000 IF: 1:100~1:500 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: CD158a polyclonal antibody detects endogenous levels of CD158a protein. Molecular Weight: ~ 49 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P43626 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. Research Use Only