Product Description

CD161 (3F8) Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB8565-50, MB8565-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. T cells bearing natural killer receptors (NKRs) such as CD94 and CD161 are present in psoriasis. CD161 mediates NK cell activation and functions as an activating receptor. CD161 is a prototypic marker of NK cells, although it is also found on a subset of CD8+ T cells. The expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector T cells that are expanded in vivo after antigenic activation leading to extensive proliferation. The transcription, mRNA accumμlation, and surface expression of CD161, a molecμle involved in triggering cytotoxicity, is specifically upregμlated by IL-12.

Category: Primary Antibody

Reactivity: Rat

Host: Mouse

Applications: WB

Alternate Names: Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids of Human CD161.

Dilution: WB: 1:500~1:2000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD161 (3F8) Monoclonal Antibody detects endogenous levels of CD161 protein.

Molecular Weight: ~ 25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q12918

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only