Product Description

CD163 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0287-500, NCP0287-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD163 is a transmembrane scavenger receptor expressed on the macrophage surface. It has 9 B-type SRCR extracellμlar domains mediating serum haptoglobin clearing/endocytosis, pathogen binding and signal transduction, and calcium binding. CD163 is used as a surface marker of M2 type macrophages, including M2 type tumor associated macrophages (TAMs), which facilitate cancer progression by secreting cytokines to promote angiogenesis, immunosuppression and metastasis. Inflammatory stimμlation and stress signal can induce extracellμlar domain shedding of CD163 to generate soluble CD163 (sCD163). The increased sCD163 level in serum is associated with low-grade inflammation in disease conditions.

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~89kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: Q86VB7

Tag: His-tag

Amino Acid Sequence: AGCAGCCTGGGCGGTACCGATAAAGAACTGCGTCTGGTGGATGGTGAAAATAAATGCAGTGGTCGTGTGGAAGTGAAAGTTCAGGAAGAATGGGGCACCGTGTGTAATAATGGTTGGAGCATGGAAGCCGTTAGCGTGATCTGTAATCAGCTGGGCTGCCCGACCGCAATTAAAGCCCCGGGCTGGGCCAATAGTAGTGCAGGCAGTGGCCGTATCTGGATGGATCATGTTAGCTGCCGTGGCAATGAAAGCGCCCTGTGGGATTGTAAACATGATGGTTGGGGCAAACATAGTAATTGTACCCATCAGCAGGATGCCGGTGTTACCTGTAGTGATGGCAGTAATCTGGAAATGCGTCTGACCCGCGGTGGCAATATGTGCAGTGGCCGTATTGAAATTAAATTCCAGGGCCGCTGGGGCACCGTGTGTGATGATAACTTCAATATTGATCATGCAAGTGTTATCTGTCGTCAGCTGGAATGTGGTAGCGCCGTTAGCTTCAGTGGCAGTAGTAACTTCGGTGAAGGCAGTGGTCCGATCTGGTTCGATGATCTGATCTGTAATGGTAATGAAAGTGCCCTGTGGAATTGTAAACATCAGGGTTGGGGTAAACATAATTGTGATCATGCCGAAGATGCCGGTGTGATCTGTAGTAAAGGCGCAGATCTGAGTCTGCGTCTGGTTGATGGTGTGACCGAATGCAGTGGTCGCCTGGAAGTTCGCTTCCAGGGTGAATGGGGTACCATCTGTGATGATGGTTGGGATAGCTATGATGCAGCAGTTGCCTGTAAACAGCTGGGCTGTCCGACCGCAGTGACCGCCATTGGTCGCGTGAATGCAAGTAAAGGCTTCGGTCATATCTGGCTGGATAGCGTTAGCTGCCAGGGCCATGAACCGGCAATCTGGCAGTGCAAACATCATGAATGGGGCAAACACTATTGTAATCATAATGAAGATGCCGGCGTGACCTGTAGTGACGGTAGTGATCTGGAACTGCGTCTTCGCGGTGGTGGCAGTCGTTGTGCAGGTACCGTTGAAGTTGAAATTCAGCGTCTGCTGGGTAAAGTGTGTGATCGCGGCTGGGGTCTGAAAGAAGCAGATGTTGTGTGCCGCCAGCTGGGTTGTGGCAGCGCCCTGAAAACCAGTTATCAGGTGTATAGTAAAATCCAGGCAACCAATACCTGGCTGTTCCTGAGCAGTTGTAATGGTAACGAAACCAGTCTGTGGGATTGCAAAAATTGGCAGTGGGGTGGCCTGACCTGTGATCATTATGAAGAAGCCAAAATTACCTGTAGCGCACATCGCGAACCGCGCCTGGTTGGCGGCGATATTCCGTGCAGTGGCCGCGTTGAAGTTAAACATGGTGATACCTGGGGCAGTATCTGTGATAGCGACTTCAGTCTGGAAGCAGCCAGCGTTCTGTGTCGCGAACTGCAGTGTGGCACCGTTGTTAGTATTCTGGGCGGCGCACACTTCGGCGAAGGCAATGGTCAGATCTGGGCAGAAGAATTCCAGTGTGAAGGTCATGAAAGCCATCTGAGTCTGTGTCCGGTTGCACCGCGTCCGGAAGGCACCTGCAGCCATAGTCGCGATGTTGGTGTTGTGTGTAGCCGCTATACCGAAATTCGTCTGGTTAATGGCAAAACACCTTGCGAAGGTCGTGTTGAACTGAAAACCTTAGGTGCCTGGGGTAGCCTGTGCAATAGTCATTGGGATATTGAAGATGCCCATGTTCTGTGCCAGCAGCTGAAATGCGGTGTTGCACTGAGTACCCCGGGCGGCGCACGCTTCGGTAAAGGTAATGGCCAGATCTGGCGTCACATGTTCCATTGCACCGGCACCGAACAGCACATGGGCGATTGTCCGGTTACCGCCCTGGGTGCCAGCCTGTGTCCGAGCGAACAGGTGGCAAGCGTGATCTGTAGCGGCAATCAGAGTCAGACCCTGAGCAGCTGCAATAGTAGCAGCCTGGGTCCGACCCGTCCGACCATTCCGGAAGAAAGCGCCGTGGCCTGCATTGAAAGCGGTCAGCTGCGTCTGGTCAATGGTGGCGGTCGTTGTGCCGGTCGTGTGGAGATCTATCATGAAGGCAGTTGGGGTACCATCTGTGACGATAGTTGGGATCTGAGCGATGCCCATGTGGTGTGTCGTCAGTTAGGTTGCGGCGAAGCCATTAATGCAACCGGTAGCGCACACTTCGGTGAAGGTACCGGTCCGATCTGGCTGGACGAAATGAAATGCAATGGTAAAGAAAGCCGTATCTGGCAGTGTCATAGCCATGGTTGGGGCCAGCAGAATTGCCGCCATAAAGAAGATGCAGGTGTTATCTGTAGCGAATTCATGAGCCTGCGCCTGACCAGTGAAGCCAGTCGCGAAGCATGCGCCGGCCGTCTGGAAGTGTTCTATAATGGTGCCTGGGGCACCGTT

Expression Vector: pet-22b(+)

Research Use Only