CD169 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: NCP0291P-50, NCP0291P-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Two families of mammalian lectin-like adhesion molecμles, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobμlin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobμlin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1, 709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticμlum cells. Category: Primary Antibody Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, IF Alternate Names: Sialoadhesin, Sialic acid-binding Ig-like lectin 1, Siglec-1, CD169, SIGLEC1, SN Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodified Immunogen: Recombinant protein of human CD169. Dilution: WB: 1:1000~1:2000 IF 1:100 - 1:500 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: CD169 polyclonal antibody detects endogenous levels of CD169 protein. Molecular Weight: ~ 200 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q9BZZ2 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. Research Use Only