Product Description

CD170 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0292-500, NCP0292-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Two families of mammalian lectin-like adhesion molecμles bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobμlin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobμlin superfamily members recognizing sialylated ligands. Siglec-5 binds equally to α2,3-linked and α2,6-linked sialic acid. There exist four isoforms of hSiglec-5 possessing three (hSiglec-5-3L and -3C) or four (hSiglec-5-4L and -4S) extracellμlar domains linked to long (hSiglec-5-3L and -4L) or short (hSiglec-5-4S) cytoplasmic tails or existing as a soluble isoform (hSiglec-5-3C). Siglec-5 is expressed by monocytes and neutrophils, but is absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec-5 may play a role in the diagnosis and monitoring of acute myeloid leukemia (AML).

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~47kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: O15389

Tag: His-tag

Amino Acid Sequence: GAAAAGCCGGTGTATGAACTGCAGGTTCAGAAAAGCGTGACCGTGCAGGAAGGCCTGTGTGTGCTGGTGCCGTGTAGCTTCAGCTATCCGTGGCGCAGCTGGTATAGTAGTCCGCCGCTGTATGTGTATTGGTTCCGCGATGGTGAAATTCCGTATTATGCCGAAGTTGTTGCCACCAATAATCCGGATCGCCGTGTTAAACCGGAAACACAAGGTCGCTTCCGCCTGCTGGGTGATGTGCAGAAAAAAAATTGTAGCCTGAGCATTGGCGATGCACGTATGGAAGATACCGGTAGCTACTTCTTCCGTGTTGAACGTGGCCGTGATGTTAAATATAGTTATCAGCAGAATAAGCTGAACCTGGAAGTTACCGCACTGATTGAAAAACCGGATATTCACTTCCTGGAACCGCTGGAAAGCGGTCGTCCGACCCGTCTGAGCTGCAGTCTGCCGGGTAGTTGCGAAGCAGGCCCGCCGCTGACCTTCAGTTGGACCGGTAATGCCCTGAGCCCGCTGGATCCGGAAACCACCCGCAGCAGTGAACTGACCCTGACCCCGCGCCCGGAAGATCATGGTACCAATCTGACCTGCCAGATGAAACGTCAGGGTGCCCAGGTGACCACCGAACGTACCGTTCAGCTGAATGTTAGTTATGCCCCGCAGACCATTACCATCTTCCGCAATGGCATTGCCCTGGAAATTCTGCAGAATACCAGCTATCTGCCGGTTCTGGAAGGTCAGGCCCTGCGCCTGCTGTGCGATGCCCCTAGTAATCCGCCGGCACATCTGAGTTGGTTCCAGGGCAGTCCGGCACTGAATGCAACCCCGATTAGCAATACCGGCATTCTGGAACTGCGCCGTGTGCGCAGTGCAGAAGAAGGTGGCTTCACCTGTCGCGCACAGCATCCGCTGGGCTTCCTGCAGATCTTCCTGAATCTGAGTGTGTATAGTCTGCCGCAGCTGCTGGGCCCGAGTTGTAGCTGGGAAGCCGAAGGTCTGCATTGCCGCTGTAGCTTCCGTGCCCGTCCGGCACCGAGCCTGTGTTGGCGTCTGGAAGAAAAACCGCTGGAAGGTAATAGCAGTCAGGGCAGCTTCAAAGTTAATAGCAGTAGTGCAGGCCCGTGGGCAAATAGCAGTCTGATTCTGCATGGCGGTCTGAGCAGCGATCTGAAAGTGAGTTGCAAAGCATGGAATATCTATGGCAGTCAGAGTGGTAGTGTGCTGCTGCTGCAGGGTCGCAGCAATCTGGGTACCGGTGTTGTGCCGGCAGCCCTG

Expression Vector: pet-22b(+)

Research Use Only