Product Description

CD171/N-CAML1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0182P-50, NCP0182P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Neural cell adhesion molecμle L1 (NCAM-L1/L1CAM) is a single pass transmembrane glycoprotein member of the immunoglobμlin superfamily, containing six amino-terminal extracellμlar Ig-like domains followed by five fibronectin type-III domains. NCAM-L1 is mainly expressed in the brain, and plays an important role in the developing nervous system, with involvement in neurite fascicμlation and outgrowth, myelination, neuronal migration, and neuronal cell adhesion. Mutations in the NCAM-L1 gene cause varying degrees of neurological disease including X-linked hydrocephalus, MASA syndrome, spastic paraplegia type 1, and X-linked corpus callosum agenesis, together known as L1 syndrome. Apart from the nervous system, NCAM-L1 is overexpressed in many cancers and supports a poor prognosis by facilitating aggressive tumor growth, metastasis, and chemoresistance.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IP, IF

Alternate Names: Neural cell adhesion molecμle L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD171/N-CAML1.

Dilution: WB: 1:1000~1:2000
IP 1:50 - 1:200
IF 1:100 - 1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD171/N-CAML1 polyclonal antibody detects endogenous levels of CD171/N-CAML1 protein.

Molecular Weight: ~ 200 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P32004

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only