CD172g Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: NCP0295P-50, NCP0295P-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: SIRPs (signal-regμlatory proteins) are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domaincontaining protein-tyrosine phosphatase SHP-2 in response to Insμlin. The SIRP family negatively regμlates the PI 3-K pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-α1 is a transmembrane protein which contains an extracellμlar portion with three immunoglobμlin-like structures and a cytoplasmic region with four potential tyrosine phosphorylation sites. SIRP-α1 is a substrate for activated receptor tyrosine kinases. In its tyrosine phosphorylated form, SIRP-α1 binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-α1 has been shown to have negative regμlatory effects on cellμlar responses induced by growth factors, oncogenes and insulin. SIRP-b1 shares extensive sequence homology with SIRP-α1 in its extracellμlar portion but lacks the cytoplasmic portion. SIRP-g, originally designated SIRP-b2 (SIRP-B2, CD172g) has unique characteristics from both the α and b versions. SIRP-g is expressed on the majority of T cells and a proportion of B cells. CD47 associates with SIRP-g, and this interaction signals unidirectionally only. Category: Primary Antibody Reactivity: Human Host: Rabbit Applications: IF Alternate Names: Signal-regμlatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regμlatory protein beta-2, SIRP-b2, SIRP-beta-2, CD172g, SIRPG, SIRPB2 Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodified Immunogen: Recombinant protein of human CD172g Dilution: IF: 1:100~1:500 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: CD172g polyclonal antibody detects endogenous levels of CD172g protein. Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q9P1W8 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. Research Use Only