Product Description

CD18 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65759-50, MB65759-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Lymphotoxin β receptor (LTβR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3) and tumor necrosis factor receptor type III (TNF-RIII), is a type I membrane receptor expressed by stromal cells, including endothelial, mesenchymal, and epithelial cells, and by myeloid cells, such as dendritic cells and macrophages. When lymphotoxin α (LTα) is co-expressed with lymphotoxin β (LTβ) that possesses a transmembrane domain, it forms a cell surface-bound heterotrimer (LTα1β2) that exclusively binds to LTβR. The LTα1β2/LTβR pathway is required for the normal development of lymph nodes and Peyer’s patches. Disruption of the LTα1β2/LTβR pathway resμlts in impaired protection from viral and bacterial infections . LTβR is also a receptor for LIGHT/TNFSF14. LTβR signaling through LIGHT/TNFSF14 regμlates self-renewal and differentiation of hematopoietic and leukemic stem cells. In cancer cells, LTβR signaling via TRAF molecμles promotes apoptosis. Agonistic antibodies to LTβR trigger cancer cell death and suppress tumor growth in vivo.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: IF, FC

Alternate Names: CD18, MFI7, Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150.95 subunit beta, Complement receptor C3 subunit beta, CD antigen CD18

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Native purified human CD18.

Dilution: IF (1/50 - 1/200)

Purification: The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes human CD18

Molecular Weight: ~ 84 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05107

Product: Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Research Use Only