Product Description

CD18 Monoclonal Antibody

Catalogue Numbers: MB65759-50, MB65759-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Swiss-Prot: P05107

Host: Mouse

Reactivity: Human

Applications: IF, FC

All Applications: IF (1/50 - 1/200)

Background: Lymphotoxin β receptor (LTβR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3) and tumor necrosis factor receptor type III (TNF-RIII), is a type I membrane receptor expressed by stromal cells, including endothelial, mesenchymal, and epithelial cells, and by myeloid cells, such as dendritic cells and macrophages. When lymphotoxin α (LTα) is co-expressed with lymphotoxin β (LTβ) that possesses a transmembrane domain, it forms a cell surface-bound heterotrimer (LTα1β2) that exclusively binds to LTβR. The LTα1β2/LTβR pathway is required for the normal development of lymph nodes and Peyer’s patches. Disruption of the LTα1β2/LTβR pathway results in impaired protection from viral and bacterial infections . LTβR is also a receptor for LIGHT/TNFSF14. LTβR signaling through LIGHT/TNFSF14 regulates self-renewal and differentiation of hematopoietic and leukemic stem cells. In cancer cells, LTβR signaling via TRAF molecules promotes apoptosis. Agonistic antibodies to LTβR trigger cancer cell death and suppress tumor growth in vivo.

Purification and Purity: The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes human CD18

Extra Notes: Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD18 Antibody, followed by anti-mouse IgG PE.

Bioworld Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150.95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18

Immunogen: Native purified human CD18.

Conjugate: Unconjugated

Modification: Unmodified