Product Description

CD19 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65760-50, MB65760-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD19 is a 95 kDa coreceptor which amplifies the signaling cascade in B cells. On the B cell surface, CD19 associates with CD21, CD81, and Leu-13 to exert its function. The cytoplasmic tail of CD19 has nine conserved tyrosine residues playing critical roles in CD19 mediated function by coupling signaling molecμles to the receptor. After B cell receptor or CD19 ligation, Tyr531 and Tyr500 of CD19 are progressively phosphorylated. This phosphorylation enables the coupling of PI3 kinase and Src family tyrosine kinase to CD19 and activates the PI3K and Src signaling pathways. Coligation of B cell receptor and CD19 also promotes Tyr409 phosphorylation in CD19. The phosphorylation at these sites enables its binding to Vav and mediates elevated intracellμlar calcium response, as well as the JNK pathway.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: IF, FC

Alternate Names: B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD antigen CD19

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Native purified human CD19.

Dilution: IF (1/50 - 1/200)

Purification: The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes human CD19

Molecular Weight: ~ 61 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P15391

Product: Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Research Use Only