CD204 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA22971-50, RA22971-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: macrophage scavenger receptor 1 (MSR1) Homo sapiens This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type Reactivity: Human, Mouse, Rat Host: Rabbit Applications: IHC-p, IF (paraffin section), ELISA Alternate Names: Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;CD antigen CD204) Clonality: Polyclonal Dilution: IHC-p 1:50-200, ELISA 1:10000-20000 Storage: -20°C/1 year Human Gene ID: 4481 Human SwissProt Number: P21757 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only