CD248 Polyclonal Antibody-BS62215

CD248 Polyclonal Antibody

Catalogue Numbers: BS62215-50, BS62215-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9HCU0

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB:1:500~1:1000

Background: Tumor endothelial marker 1 (TEM1/endosialin) is a heavily glycosylated, type I transmembrane C-type lectin-like receptor of the Ras superfamily expressed in the vascular endothelium and on fibroblast-like cells in developing organs. Expression of TEM1 largely disappears in adulthood. TEM1 is structurally related to thrombomodulin and complement receptor C1qRp. It consists of three EGF-like domains, a C-type lectin domain and a Sushi domain. TEM1 is highly upregulated in tumor endothelium and is known to function in tumor growth and progression. For this reason TEM1 is a major target in anti-angiogenic tumor therapy. TEM1 may be responsible for concentrating liposomes on the surface of target cells and promoting their fusion with the cell membrane.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD248 polyclonal antibody detects endogenous levels of CD248 protein.

Extra Notes: Western blot analysis of extracts of HepG2 and Hela cell line, using CD248 polyclonal antibody.

Bioworld Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Endosialin; Tumor endothelial marker 1; CD164L1; TEM1

Immunogen: Synthetic peptide, corresponding to Human CD248.

Conjugate: Unconjugated

Modification: Unmodified