Product Description

CD252 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66937-50, MB66937-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: OX40 is a member of the tumor necrosis factor receptor superfamily that regμlates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and resμlts in the formation of a TCR-independent signaling complex. One component of this complex, PKC胃, activates the NF-魏B pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: TXGP1, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, CD252

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD252. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/2000)

Specificity: Recognizes endogenous levels of CD252 protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P23510

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only