Product Description

CD273 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65846-50, MB65846-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Programmed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regμlate T-cell activation and immune responses. PD-L2 binds the PD-1 transmembrane receptor and inhibits T-cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T-cells. Similar in structure to related B7 family members, PD-L2 protein contains extracellμlar IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma.

Category: Primary Antibody

Reactivity: Mouse

Host: Mouse

Applications: IF, FC

Alternate Names: B7DC, CD273, PDCD1L2, PDL2, Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Mouse B7-DC transfected cell line

Dilution: IF (1/50 - 1/200)

Purification: The monoclonal antibody was affinity-purified from Mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes mouse CD273

Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Wμl5

Product: Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Research Use Only