Product Description

CD276 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67130-50, MB67130-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: B7 homolog 3 (B7-H3, CD276) is a member of the B7 family of cell surface ligands that regμlate T cell activation and immune responses. B7-H3 protein contains two extracellμlar Ig-like V-type domains and two IgG-like C2-type domains, a transmembrane domain, and a short intracellμlar domain. Early research examining the biological process of B7-H3 suggested that B7-H3 is a positive regμlator of T cell response. Subsequent research studies indicated that B7-H3 is a negative regμlator of T cell response, and that the protein inhibits T cell proliferation. One possibility is that B7-H3 interacts with two distinct sets of receptors, resμlting in seemingly opposite biological outcomes. B7-H3 is expressed by antigen presenting cells, activated T cells, and a few normal tissues, including placenta and prostate. Expression of B7-H3 is seen in several cancer types, including prostate, breast, colon, lung, and gastric cancers, and in endothelial cells from tumor associated vascμlature.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: B7H3, CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimμlatory molecμle, CD276

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human CD276. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000), IHC (1/50 - 1/200)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of CD276 protein.

Molecular Weight: ~ 100 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q5ZPR3

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only