Product Description

CD28 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65740-50, BS65740-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Human CD28 antigen is a 44 kDa disμlfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecμle of the immunoglobμlin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells resμlts in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide MHC complexes, and the second is delivered by accessory or costimμlating molecμles through their counter receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ and CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells and on interferon gamma treated monocytes. The binding of B7 1/BB 1 molecμles to CD28 is involved in T lymphocyte activation and in the initiation and maintenance of chronic inflammation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse

Host: Rabbit

Applications: WB

Alternate Names: CD 28, CD28 antigen, CD28 molecμle, MGC138290, T cell antigen CD28, T cell specific surface glycoprotein, T cell specific surface glycoprotein CD28, Tp44.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from mouse CD28:1-120/218

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: CD28 Polyclonal Antibody detects endogenous levels of CD28 protein.

Molecular Weight: 50 kD，44kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P31041

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only