Product Description

CD282 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66730-50, MB66730-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Six human homologs of the Drosophila toll receptor were initially identified based on their sequence similarities and designated Toll-like receptors (TLR). Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo and also participate in the host immunity. The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellμlar domain that consists of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimμlation, which resμlts in the activation and translocation of NFκB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of the TLR family, it induces NFκB signaling upon activation.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: TIL4, Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human CD282. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of CD282 protein.

Molecular Weight: ~ 84 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60603

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only