CD282 Monoclonal Antibody-MB66730

CD282 Monoclonal Antibody

Catalogue Numbers: MB66730-50, MB66730-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: O60603

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Six human homologs of the Drosophila toll receptor were initially identified based on their sequence similarities and designated Toll-like receptors (TLR). Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo and also participate in the host immunity. The TLR family of proteins are characterized by a highly conserved Toll homology (TH)
domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain that consists of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFκB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of the TLR family, it induces NFκB signaling upon activation.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of CD282 protein.

Extra Notes: Western blot analysis of CD282 expression in Ramos (A), A549 (B), MDAMB231 (C) whole cell lysates.

Bioworld Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282

Immunogen: Recombinant fusion protein of human CD282. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified