CD299 rabbit pAb - ES8703

CD299 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8703-50, ES8703-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations

Alternate Name: C-type lectin domain family 4 member M (CD209 antigen-like protein 1; DC-SIGN-related protein; DC-SIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; DC-SIGN2; Liver/lymph node-specific ICAM-3-grabbing non-integrin; L-SIGN; CD antigen CD299)

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthetic peptide from human protein at AA range: 271-320

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 60kD

Human Gene ID: 10332

Human SWISS Prot NO: Q9H2X3

Subcellular Location: [Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 10]: Secreted.

Research Use Only