Product Description

CD30 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66955-50, MB66955-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TNFRSF8/CD30 is a type-I transmembrane glycoprotein that is a member of the TNFR superfamily. CD30 is synthesized as a precursor protein that undergoes extensive post-translational modification before becoming embedded in the plasma membrane as a 120-kDa transmembrane protein . The expression of CD30 is upregμlated in activated T cells and may trigger costimμlatory signaling pathways upon its engagement . While its expression is normally restricted to subsets of activated T cells and B cells, CD30 expression is robustly upregμlated in hematologic malignancies, such as Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and adμlt T-cell leukemia, thus making it an attractive target for therapeutic intervention . Research studies have suggested that in certain disease contexts, CD30 recruits TRAF2 and TRAF5 adaptor proteins to drive NF-kappa B activation, aberrant cell growth, and cytokine production . CD30 signaling is also regμlated by TACE-dependent proteolytic cleavage of its ectodomain, which resμlts in reduced CD30L-dependent activation of CD30+ cells .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: CD30, D1S166E, Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD30. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of CD30 protein.

Molecular Weight: ~ 95 kDa

Pathway: PI3K AKT signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P28908

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only