Product Description

CD305 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: NCP0313P-50, NCP0313P-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: Q6GTX8

Host: Rabbit

Reactivity: Human

Applications: WB,

All Applications: WB: 1:1000~1:2000

Background: LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD305 polyclonal antibody detects endogenous levels of CD305 protein.

Bioworld Molecular Weight: ~ 46 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CD305 polyclonal antibody at 1:1000 dilution
Lane 1: THP-1 whole cell lysate (30ug
Lane 2: L02 cell membrane lysate (24ug)
Lane 3: MCF-7 cell membrane lysate (24ug)

Alternative Name: Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; LAIR1

Immunogen: Recombinant protein of human CD305.

Conjugate: Unconjugated

Modification: Unmodified